To win big at casino blackjack, players should employ effective strategies such as basic strategy charts, which dictate the optimal play based on their hand and the dealer's upcard. Additionally, card counting can provide an edge by tracking high and low cards, allowing players to adjust their bets accordingly. Managing bankroll wisely and setting win/loss limits are crucial for maintaining discipline. Lastly, taking advantage of favorable rules, such as surrender options and double down opportunities, can enhance winning potential. By combining these strategies, players can significantly improve their chances of success at the blackjack table.